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A Case Study of Formulating ‘One and Done’ Daily Dosing Involving a Highly Water-Soluble API

The Issue
Metrics Contract Services was approached by a client with a commercialized drug product indicated for curative treatment. The client needed a second-generation formulation for a clinical trial studying the drug’s efficacy as a preventative treatment. The clinical trial would enroll patients for whom medication compliance would be extremely difficult. So the client hoped to encourage patient compliance with an easy and palatable “one and done” daily dosing.

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